Dissertation > Excellent graduate degree dissertation topics show
Relationship of S100B and ICP to Clinical Severity and Prognosis after Traumatic Brain Injury
Author: ZuoChangFeng
Tutor: LiuZhiXiong
School: Central South University
Course: Clinical
Keywords: Traumatic brain injury S100B protein Intracranial pressure
CLC: R651.15
Type: Master's thesis
Year: 2013
Downloads: 14
Quote: 0
Read: Download Dissertation
Abstract
Objective:Biomarkers may offer diagnostic and prognostic tools in addition to clinical indices after traumatic brain injury (TBI). The most recognizable neurocritical emergency is the acute elevation of intracranial pressure (ICP) and S100B is a protein biomarker that reflects CNS injury. It can be measured in the CSF or serum. This study aims to investigate the relationship of S100B and ICP to clinical severity and prognosis after TBI. Analysis of the relation between S100B and ICP was undertaken. Methods:Forty-five patients at the Xiang Ya Hospital enrolled from Mar. to Oct. in2011were classified into3cohorts according to Glasgow score (GCS score):minor grade, moderate and severe(case group),25cases of them were treated with an ICP monitoring(ICP monitoring group). ICP monitoring group was divided into4groups:normal (<15mmHg), light (15~20mmHg), moderate (21~40mmHg) and heavy (>40mmHg). S100B levels were analyzed in CSF and serum collected1day,3day,5day,7day after TBI by ELISA. ICP datum and GCS scores were recorded in ICP monitoring group meantime. Respectively6operative patients with hernia or varicose vein whose S100B levels in CSF and serum were used as control group. Outcome was assessed using the Glasgow Outcome Scale(GOS score). GOS scores dichotomised as unfavourable (GOS1-3) and favourable (GOS4-5)were collected6months after TBI. SPSS17.0was applied to investigate the relationship of S100B and ICP to clinical severity and prognosis after TBI. Analysis of the relation between S100B and ICP was undertaken. Results:1. Differences of S100B levels in serum and CSF among different case groups being significant. GCS scores were negatively correlated with S100B levels in serum and CSF. Positive correlation was found between S100B levels in serum and in CSF in case groups. We proved significantly higher values of S100B in serum and CSF in unfavourable outcome group. S100B levels were negatively associated with GOS scores.2. ICP had a negative correlation GCS scores and GOS scores.3. The differences of S100B level among different initial ICP were statistical significance. There is a positive correlation between S100B levels in serum and CSF with ICP. Conclusion:1. S100B protein, as a neuronal specific biomarker, can be measured in serum and CSF used as a significant biochemical marker for severity and prognosis after TBI;2. ICP monitoring is a important physiological index related closely with severity and prognosis after TBI;3. In conjunction with clinical manifestation and radiologic evidence, uniting monitoring S100B and ICP may serve to enhance prediction of early clinical trends following TBI.
|
Related Dissertations
- The Effect of Mild Hypothermia Combined with TP-5 to T Lymphocyte Subsets and Prognosis of Patients with Severe Traumatic Brain Injur,R651.15
- The Expression Mechanism of Calmodulin in Rat with Brain Contusion,R651.1
- The Nursing Evaluation on Effects of Endovascular Hypothermia for Severe Traumatic Brain Injury,R473.6
- A Study on Molecular Mechanism of Cognitive Deficits After Traumatic Brain Injury,R651.15
- Neonatal HIE S100B and NSE serum concentrations and the clinical significance,R722.1
- Experimental Study on the Efficacy and Underlying Mechanism of Hyperbaric Oxygen Treatment for Traumatic Brain Injury,R651.15
- Progesterone Regulates the Expression of COX-2 and Caspase-3 Via NF-κB Signaling Pathway in Hippocampal Neurons after Traumatic Brain Injury in Rats,R651.15
- The Factors Associated with Mental Health Status of Family Members of Patients with Traumatic Brain Injury by Different Treatments,R473.6
- Dynamic Observation in Minimally Invasive Treatment of Cerebral Hemorrhage,R743.34
- A Long-term Neuroprotective Effect of Sevoflurane Postconditioning on Traumatic Brain Injury in Rats and the Role of PI3K/Akt Pathway,R614
- An Experimental Research of the Changes of Cerebral AQP-4 Expression after Decompressive Craniectomy,R651.15
- Clincial Research of Early Hyperbaric Oxygen Treatment on the patients after Craniortomy with Severe Traumatic Brain Injury,R651.15
- Severe Brain Injury Accidents of Pre-Hospital,Hospital Emergency and Prognosis,R651.1
- The Effects of Brain-derived Neurotrophic Factor during Fracture Healing in Brain Injury Associated with Fracture,R651.1
- Correlation of Intracranial Pressure with Parameters of Coagulation and T-lymphocyte Subsets in Patients Following Acute Moderate Traumatic Brain Injury:clinical Study,R651.15
- Application of Ultrasound in Traumatic Brain Injury Operation under the Conditions of the Field Hospital,R82
- The Effects of Propofol on the Cerebral Edema and the Expression of AQP-4 after the Traumatic Brain Injury in Rat,R96
- The Effect of Traumatic and Non-traumatic Stress on Circulating Endothelial Progenitor Cells in Rats,R363
- rhEPO Enhances the Mobilization of EPCs and Improves the Neurofunctional Recovery in TBI Rats,R96
- The Basal and Clinical Researches on the Relationship between the Cerebrospinal Fluid Protein S100B Concentrations and the Prognosis of Comatose Patients,R741
- Treatment of intracranial hypertension,R741
CLC: > Medicine, health > Surgery > Of surgery > Head and Neurosurgery > Brain > Traumatic brain injury
© 2012 www.DissertationTopic.Net Mobile
|