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An Experimental Research on the Cholinergic Pathogenesis of Vascular Dementia

Author: LiYongSheng
Tutor: ShaoFuYuan
School: Second Military Medical University
Course: Neurology
Keywords: Vascular Dementia Cholinergic neurons Hemlock alkali acetylcholine receptor Nicotinic acetylcholine receptor CAMP response element binding protein 2-VO model Primary cultured Protein phosphorylation
CLC: R749.16
Type: PhD thesis
Year: 2004
Downloads: 459
Quote: 1
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Abstract


In vivo and in vitro studies central cholinergic nervous system in the role and mechanism of the formation of vascular dementia (VaD) cognitive dysfunction . VaD model rat basal forebrain ischemic irreversible pathological changes under in vivo conditions , the development over time , cholinergic neuronal injury , nicotinic acetylcholine receptor the largest combined with volume reduction , cAMP response element binding protein . (CREB) phosphorylation of the lower level as well as the VaD rat learning and memory ability , application cholinesterase inhibitors can improve learning and memory in rats ; vitro hypoxia under experimental conditions , primary cultured hippocampal neurons CREB phosphorylation levels decreased and shorten the length of the protrusions , application of muscarinic and nicotinic acetylcholine receptor agonist , can improve the level of CREB phosphorylation and neurite length . Accordingly, we believe that chronic cerebral hypoperfusion central cholinergic neuronal damage, decline in ability to synthesis of acetylcholine molecules , the decrease in the number of receptors in the postsynaptic receptor subtype signal transduction pathway dysfunction , resulting in CREB phosphorylation levels reduce , thereby affecting synaptic plasticity and the formation of the neural network , which eventually led VaD cognitive dysfunction .

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CLC: > Medicine, health > Neurology and psychiatry > Psychiatry > Cerebral organic mental disorder > Elderly as early as possible the old disorder
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